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Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency
Autosomal dominant polycystic kidney disease (ADPKD) is a common kidney disease caused by mutations in PKD1 or PKD2. Metformin reduces cyst growth in mouse models of PKD1. However, metformin has not been studied in animal models of PKD2, and the cellular mechanism underlying its effectiveness is not...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5541071/ https://ncbi.nlm.nih.gov/pubmed/28769124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07300-x |
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