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Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold()
A novel and simplified synthetic scaffold based on pladienolide was designed using a consensus pharmacophore hypothesis. An initial target was synthesized and evaluated to examine the role of the 3-hydroxy group and the methyl groups present at positions 10, 16, 20, 22 in 1, on biological activity....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3171832/ https://ncbi.nlm.nih.gov/pubmed/21927710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1MD00040C |
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