High-Throughput Kinase Profiling: A More Efficient Approach towards the Discovery of New Kinase Inhibitors

Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that “high-throughput kinase profiling” is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. We screened a library of...

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Hauptverfasser: Miduturu, Chandrasekhar V., Deng, Xianming, Kwiatkowski, Nicholas, Yang, Wannian, Brault, Laurent, Filippakopoulos, Panagis, Chung, Eunah, Yang, Qingkai, Schwaller, Juerg, Knapp, Stefan, King, Randall W., Lee, Jiing-Dwan, Herrgard, Sanna, Zarrinkar, Patrick, Gray, Nathanael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171802/
https://ncbi.nlm.nih.gov/pubmed/21802008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.05.010
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