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Understanding the limitations of radiation-induced cell cycle checkpoints

The DNA damage response pathways involve processes of double-strand break (DSB) repair and cell cycle checkpoint control to prevent or limit entry into S phase or mitosis in the presence of unrepaired damage. Checkpoints can function to permanently remove damaged cells from the actively proliferatin...

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Autori principali: Deckbar, Dorothee, Jeggo, Penny A, Lobrich, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Informa Healthcare 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171706/
https://ncbi.nlm.nih.gov/pubmed/21524151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2011.575764
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