Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate

We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assay system containing Fluor-de-Lys as a fluorescent substrate. The experimental data reveals that such act...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Singh, Raushan K., Mandal, Tanmay, Balsubramanian, Narayanaganesh, Viaene, Tajae, Leedahl, Travis, Sule, Nitesh, Cook, Gregory, Srivastava, D.K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171571/
https://ncbi.nlm.nih.gov/pubmed/21865040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.07.080
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы