Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial

BACKGROUND: In the development of HIV vaccines, improving immunogenicity while maintaining safety is critical. Route of administration can be an important factor. METHODOLOGY/PRINCIPAL FINDINGS: This multicenter, open-label, randomized trial, HVTN 069, compared routes of administration on safety and...

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Detalhes bibliográficos
Main Authors: Koblin, Beryl A., Casapia, Martin, Morgan, Cecilia, Qin, Li, Wang, Zhixue Maggie, Defawe, Olivier D., Baden, Lindsey, Goepfert, Paul, Tomaras, Georgia D., Montefiori, David C., McElrath, M. Juliana, Saavedra, Lilian, Lau, Chuen-Yen, Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Clinical Trial
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171485/
https://ncbi.nlm.nih.gov/pubmed/21931737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024517
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