Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial

BACKGROUND: In the development of HIV vaccines, improving immunogenicity while maintaining safety is critical. Route of administration can be an important factor. METHODOLOGY/PRINCIPAL FINDINGS: This multicenter, open-label, randomized trial, HVTN 069, compared routes of administration on safety and...

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Hauptverfasser: Koblin, Beryl A., Casapia, Martin, Morgan, Cecilia, Qin, Li, Wang, Zhixue Maggie, Defawe, Olivier D., Baden, Lindsey, Goepfert, Paul, Tomaras, Georgia D., Montefiori, David C., McElrath, M. Juliana, Saavedra, Lilian, Lau, Chuen-Yen, Graham, Barney S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Clinical Trial
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171485/
https://ncbi.nlm.nih.gov/pubmed/21931737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024517
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