Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults

BACKGROUND: A phase 1 trial of a clade B HIV vaccine in HIV-uninfected adults evaluated the safety and immunogenicity of a DNA prime co-expressing GM-CSF (Dg) followed by different numbers and intervals of modified vaccinia Ankara Boosts (M). Both vaccines produce virus-like particles presenting mem...

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Publicado no:PLoS One
Main Authors: Buchbinder, Susan P., Grunenberg, Nicole A., Sanchez, Brittany J., Seaton, Kelly E., Ferrari, Guido, Moody, M. Anthony, Frahm, Nicole, Montefiori, David C., Hay, Christine M., Goepfert, Paul A., Baden, Lindsey R., Robinson, Harriet L., Yu, Xuesong, Gilbert, Peter B., McElrath, M. Juliana, Huang, Yunda, Tomaras, Georgia D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519050/
https://ncbi.nlm.nih.gov/pubmed/28727817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179597
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