Ablation of the Retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression. We have generated an isogenic set of embryonic stem (ES) cell lines carrying single or compoun...

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Publié dans:	Genes Dev
Auteurs principaux:	Dannenberg, Jan-Hermen, van Rossum, Agnes, Schuijff, Leontine, te Riele, Hein
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 2000
Sujets:	Research Paper
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.847700
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