Ablation of the Retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression. We have generated an isogenic set of embryonic stem (ES) cell lines carrying single or compoun...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Dannenberg, Jan-Hermen, van Rossum, Agnes, Schuijff, Leontine, te Riele, Hein
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2000
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.847700
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