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Anti-Markovnikov Hydroalkylation of Allylic Amine Derivatives via a Palladium–Catalyzed Reductive Cross-Coupling Reaction

A palladium-catalyzed hydroalkylation reaction of allylic amine derivatives by alkylzinc reagents is reported. This reductive cross-coupling yields anti-Markovnikov products using a variety of allylic amine protecting groups. Preliminary mechanistic studies suggest that a reversible β-hydride elimin...

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Hlavní autoři: DeLuca, Ryan J., Sigman, Matthew S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170748/
https://ncbi.nlm.nih.gov/pubmed/21728336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204080s
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