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Nuclear organization of DNA replication in primary mammalian cells

Using methods that conserve nuclear architecture, we have reanalyzed the spatial organization of the initiation of mammalian DNA synthesis. Contrary to the commonly held view that replication begins at hundreds of dispersed nuclear sites, primary fibroblasts initiate synthesis in a limited number of...

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Udgivet i:Genes Dev
Principais autores: Kennedy, Brian K., Barbie, David A., Classon, Marie, Dyson, Nicholas, Harlow, Ed
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317063/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11090133/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.842600
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