Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D(2) Receptor Occupancy of Olanzapine in Rats

PURPOSE: A mechanism-based PK-PD model was developed to predict the time course of dopamine D(2) receptor occupancy (D(2)RO) in rat striatum following administration of olanzapine, an atypical antipsychotic drug. METHODS: A population approach was utilized to quantify both the pharmacokinetics and p...

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Hauptverfasser: Johnson, Martin, Kozielska, Magdalena, Pilla Reddy, Venkatesh, Vermeulen, An, Li, Cheryl, Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2011
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170473/
https://ncbi.nlm.nih.gov/pubmed/21647790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0477-7
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