Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D(2) Receptor Occupancy of Olanzapine in Rats

PURPOSE: A mechanism-based PK-PD model was developed to predict the time course of dopamine D(2) receptor occupancy (D(2)RO) in rat striatum following administration of olanzapine, an atypical antipsychotic drug. METHODS: A population approach was utilized to quantify both the pharmacokinetics and p...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Johnson, Martin, Kozielska, Magdalena, Pilla Reddy, Venkatesh, Vermeulen, An, Li, Cheryl, Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer US 2011
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170473/
https://ncbi.nlm.nih.gov/pubmed/21647790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0477-7
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla