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RANK is essential for osteoclast and lymph node development

The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK(−/−) mice were characterized by profound osteopetrosis resulting from an apparent block in osteoclast differentiation. RANK expression was not required for the commitment,...

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Publicado no:Genes Dev
Principais autores: Dougall, William C., Glaccum, Moira, Charrier, Keith, Rohrbach, Kathy, Brasel, Kenneth, De Smedt, Thibaut, Daro, Elizabeth, Smith, Jeffery, Tometsko, Mark E., Maliszewski, Charles R., Armstrong, Allison, Shen, Victor, Bain, Steven, Cosman, David, Anderson, Dirk, Morrissey, Philip J., Peschon, Jacques J., Schuh, JoAnn
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317030/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500098/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.18.2412
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