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Cellular prion protein protects from inflammatory and neuropathic pain

Cellular prion protein (PrP(C)) inhibits N-Methyl-D-Aspartate (NMDA) receptors. Since NMDA receptors play an important role in the transmission of pain signals in the dorsal horn of spinal cord, we thus wanted to determine if PrP(C )null mice show a reduced threshold for various pain behaviours. We...

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Autori principali: Gadotti, Vinicius M, Zamponi, Gerald W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170224/
https://ncbi.nlm.nih.gov/pubmed/21843375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-59
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