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Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle

Cdc6 is essential for eukaryotic DNA replication. We have mutated highly conserved CDK phosphorylation sites in Cdc6. Contrary to their reported phenotypes in human cells, unphosphorylatable ΔCDK mutants fully support DNA replication in Xenopus eggs. WtCdc6 is actively exported from the nucleus, whi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pelizon, Cristina, Madine, Mark A., Romanowski, Piotr, Laskey, Ronald A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC316983/
https://ncbi.nlm.nih.gov/pubmed/11018019
Tagiau: Ychwanegu Tag
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