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The bHLH gene Hes1 is essential for expansion of early T cell precursors

Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell diffe...

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Bibliografiske detaljer
Main Authors: Tomita, Koichi, Hattori, Masakazu, Nakamura, Eijiro, Nakanishi, Shigetada, Minato, Nagahiro, Kageyama, Ryoichiro
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316958/
https://ncbi.nlm.nih.gov/pubmed/10323870
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