Dynamic expression and essential functions of Hes7 in somite segmentation

The basic helix–loop–helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior–posterior polarity is d...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Bessho, Yasumasa, Sakata, Ryoichi, Komatsu, Suguru, Shiota, Kohei, Yamada, Shuichi, Kageyama, Ryoichiro
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2001
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312810/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11641270/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.930601
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