Protease-Sensitive Conformers in Broad Spectrum of Distinct PrP(Sc) Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate

The origin, range, and structure of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD), are largely unknown. To investigate the molecular mechanism responsible for the broad phenotypic variability of sCJD, we analyzed the conformational characteristics of p...

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Bibliografiske detaljer
Main Authors: Kim, Chae, Haldiman, Tracy, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Sy, Man-Sun, Cohen, Mark, Safar, Jiri G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169556/
https://ncbi.nlm.nih.gov/pubmed/21931554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002242
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