Protease-Sensitive Conformers in Broad Spectrum of Distinct PrP(Sc) Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate

The origin, range, and structure of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD), are largely unknown. To investigate the molecular mechanism responsible for the broad phenotypic variability of sCJD, we analyzed the conformational characteristics of p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kim, Chae, Haldiman, Tracy, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Sy, Man-Sun, Cohen, Mark, Safar, Jiri G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169556/
https://ncbi.nlm.nih.gov/pubmed/21931554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002242
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