Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

BACKGROUND: The HIV-1 accessory protein Nef is an important determinant of lentiviral pathogenicity that contributes to disease progression by enhancing viral replication and other poorly understood mechanisms. Nef mediates diverse functions including downmodulation of cell surface CD4 and MHC Class...

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Bibliografske podrobnosti
Main Authors: Olivieri, Kevin C, Mukerji, Joya, Gabuzda, Dana
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169461/
https://ncbi.nlm.nih.gov/pubmed/21819585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-64
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