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Evidence for Adaptive Evolution at the Divergence Between Lymphoid and Brain HIV-1 nef Genes

Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND). The role of HIV Nef and other accessory proteins in HAND pathogenesis is unclear. To determine whether HIV nef undergoes adaptive selection in brain, we...

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Detalhes bibliográficos
Main Authors: Olivieri, Kevin C., Agopian, Kristin A., Mukerji, Joya, Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933169/
https://ncbi.nlm.nih.gov/pubmed/20377428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2009.0257
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