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CD4 and MHC class I down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

HIV-1 nef undergoes adaptive evolution in the CNS, reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and the pathogenesis of HIV-associated dementia (HAD) is unclear. In this study, we c...

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Bibliografiske detaljer
Udgivet i:J Neurovirol
Main Authors: Gray, Lachlan R., Gabuzda, Dana, Cowley, Daniel, Ellett, Anne, Chiavaroli, Lisa, Wesselingh, Steven L., Churchill, Melissa J., Gorry, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395859/
https://ncbi.nlm.nih.gov/pubmed/21165790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-010-0001-6
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