Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

BACKGROUND: Both epidemiological and experimental studies suggest that heterozygosity for a single gene is linked with tumorigenesis and heterozygosity for two genes increases the risk of tumor incidence. Our previous work has demonstrated that Atm/Brca1 double heterozygosity leads to higher cell tr...

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Autors principals: Wang, Jufang, Su, Fengtao, Smilenov, Lubomir B, Zhou, Libin, Hu, Wentao, Ding, Nan, Zhou, Guangming
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169458/
https://ncbi.nlm.nih.gov/pubmed/21849032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-6-96
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