Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis

BACKGROUND: In recent years data from both mouse models and human tumors suggest that loss of one allele of genes involved in DNA repair pathways may play a central role in genomic instability and carcinogenesis. Additionally several examples in mouse models confirmed that loss of one allele of two...

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Bibliographic Details
Main Authors: Su, Fengtao, Smilenov, Lubomir B, Ludwig, Thomas, Zhou, Libin, Zhu, Jiayun, Zhou, Guangming, Hall, Eric J
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834696/
https://ncbi.nlm.nih.gov/pubmed/20175908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-5-15
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