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Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis
BACKGROUND: In recent years data from both mouse models and human tumors suggest that loss of one allele of genes involved in DNA repair pathways may play a central role in genomic instability and carcinogenesis. Additionally several examples in mouse models confirmed that loss of one allele of two...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834696/ https://ncbi.nlm.nih.gov/pubmed/20175908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-5-15 |
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