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Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25

Binding of 14-3-3 proteins near the nuclear localization sequence of Xenopus Cdc25 suppresses its ability to induce entry into mitosis. We have examined the intracellular localization of green fluorescent protein (GFP)-tagged wild-type Cdc25 or a mutant (S287A) that cannot bind 14-3-3 proteins. Upon...

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Detalhes bibliográficos
Main Authors: Kumagai, Akiko, Dunphy, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316939/
https://ncbi.nlm.nih.gov/pubmed/10323858
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