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The structural basis of RNA-catalyzed RNA polymerization

Early life presumably required polymerase ribozymes capable of replicating RNA. Known polymerase ribozymes best approximating such replicases use as their catalytic engine an RNA-ligase ribozyme originally selected from random RNA sequences. Here, we report 3.15 Å crystal structures of this ligase t...

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Bibliografiske detaljer
Main Authors: Shechner, David M., Bartel, David P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169305/
https://ncbi.nlm.nih.gov/pubmed/21857665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2107
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