Notochord repression of endodermal Sonic hedgehog permits pancreas development

Notochord signals to the endoderm are required for development of the chick dorsal pancreas. Sonic hedgehog (SHH) is normally absent from pancreatic endoderm, and we provide evidence that notochord, in contrast to its effects on adjacent neuroectoderm where SHH expression is induced, represses SHH e...

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Pubblicato in:	Genes Dev
Autori principali:	Hebrok, Matthias, Kim, Seung K., Melton, Douglas A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1998
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316875/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620856/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1705
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