Transgenic Expression of Human LAMA5 Suppresses Murine Lama5 mRNA and Laminin α5 Protein Deposition

Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli. As a tool to begin to understand factors regulating the expression of the LAMA5 gene, we generated transgenic mice carrying the human LAMA5 locus...

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Detalhes bibliográficos
Main Authors: Steenhard, Brooke M., Zelenchuk, Adrian, Stroganova, Larysa, Isom, Kathryn, St. John, Patricia L., Andrews, Glen K., Peterson, Kenneth R., Abrahamson, Dale R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168496/
https://ncbi.nlm.nih.gov/pubmed/21915268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023926
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