Deletion of Von Hippel-Lindau in Glomerular Podocytes Results in Glomerular Basement Membrane Thickening, Ectopic Subepithelial Deposition of Collagen α1α2α1(IV), Expression of Neuroglobin, and Proteinuria

Vascular endothelial growth factor, which is critical for blood vessel formation, is regulated by hypoxia inducible transcription factors (HIFs). A component of the E3 ubiquitin ligase complex, von Hippel-Lindau (VHL) facilitates oxygen-dependent polyubiquitination and proteasomal degradation of HIF...

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Bibliografische gegevens
Hoofdauteurs: Steenhard, Brooke M., Isom, Kathryn, Stroganova, Larysa, St. John, Patricia L., Zelenchuk, Adrian, Freeburg, Paul B., Holzman, Lawrence B., Abrahamson, Dale R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2010
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Regular Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893653/
https://ncbi.nlm.nih.gov/pubmed/20522651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090767
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