Upregulated Expression of Integrin α1 in Mesangial Cells and Integrin α3 and Vimentin in Podocytes of Col4a3-Null (Alport) Mice

Alport disease in humans, which usually results in proteinuria and kidney failure, is caused by mutations to the COL4A3, COL4A4, or COL4A5 genes, and absence of collagen α3α4α5(IV) networks found in mature kidney glomerular basement membrane (GBM). The Alport mouse harbors a deletion of the Col4a3 g...

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Hauptverfasser: Steenhard, Brooke M., Vanacore, Roberto, Friedman, David, Zelenchuk, Adrian, Stroganova, Larysa, Isom, Kathryn, St. John, Patricia L., Hudson, Billy G., Abrahamson, Dale R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517557/
https://ncbi.nlm.nih.gov/pubmed/23236390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050745
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