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Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer

RET, a gene causatively mutated in Hirschsprung disease and cancer, has recently been implicated in breast cancer estrogen (E2) independence and tamoxifen resistance. RET displays both E2 and retinoic acid (RA)-dependent transcriptional modulation in E2-responsive breast cancers. However, the regula...

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Autors principals: Stine, Zachary E., McGaughey, David M., Bessling, Seneca L., Li, Shengchao, McCallion, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168285/
https://ncbi.nlm.nih.gov/pubmed/21737465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr291
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