Genome-wide identification of conserved regulatory function in diverged sequences

Plasticity of gene regulatory encryption can permit DNA sequence divergence without loss of function. Functional information is preserved through conservation of the composition of transcription factor binding sites (TFBS) in a regulatory element. We have developed a method that can accurately ident...

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Autori principali: Taher, Leila, McGaughey, David M., Maragh, Samantha, Aneas, Ivy, Bessling, Seneca L., Miller, Webb, Nobrega, Marcelo A., McCallion, Andrew S., Ovcharenko, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2011
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129256/
https://ncbi.nlm.nih.gov/pubmed/21628450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.119016.110
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