osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG(−/−) mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bo...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Bucay, Nathan, Sarosi, Ildiko, Dunstan, Colin R., Morony, Sean, Tarpley, John, Capparelli, Casey, Scully, Sheila, Tan, Hong Lin, Xu, Weilong, Lacey, David L., Boyle, William J., Simonet, W. Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1998
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316769/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573043/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.9.1260
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