osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG(−/−) mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bo...

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Auteurs principaux: Bucay, Nathan, Sarosi, Ildiko, Dunstan, Colin R., Morony, Sean, Tarpley, John, Capparelli, Casey, Scully, Sheila, Tan, Hong Lin, Xu, Weilong, Lacey, David L., Boyle, William J., Simonet, W. Scott
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 1998
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC316769/
https://ncbi.nlm.nih.gov/pubmed/9573043
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