Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects

Flies with mutations in the single Drosophila Adar gene encoding an RNA editing enzyme involved in editing 4% of all transcripts have severe locomotion defects and develop age-dependent neurodegeneration. Vertebrates have two ADAR-editing enzymes that are catalytically active; ADAR1 and ADAR2. We sh...

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Bibliografiske detaljer
Main Authors: Keegan, Liam P., McGurk, Leeane, Palavicini, Juan Pablo, Brindle, James, Paro, Simona, Li, Xianghua, Rosenthal, Joshua J. C., O'Connell, Mary A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167634/
https://ncbi.nlm.nih.gov/pubmed/21622951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr423
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