Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

Ataxia telangiectasia (ATM) mutated and Artemis, the proteins defective in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency (RS-SCID), respectively, function in the repair of DNA double strand breaks (DSBs), which arise in heterochromatic DNA (HC-DSBs) following e...

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Detalhes bibliográficos
Main Authors: Woodbine, Lisa, Brunton, H., Goodarzi, A. A., Shibata, A., Jeggo, P. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167608/
https://ncbi.nlm.nih.gov/pubmed/21596788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr331
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