Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding

Interferon regulatory factors IRF-3 and IRF-7 are transcription factors essential in the activation of interferon-β (IFN-β) gene in response to viral infections. Although, both proteins recognize the same consensus IRF binding site AANNGAAA, they have distinct DNA binding preferences for sites in vi...

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Hlavní autoři: De Ioannes, Pablo, Escalante, Carlos R., Aggarwal, Aneel K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167601/
https://ncbi.nlm.nih.gov/pubmed/21596780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr325
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