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Quantitative impact of thymic selection on Foxp3(+) and Foxp3(−) subsets of self-peptide/MHC class II-specific CD4(+) T cells

It is currently thought that T cells with specificity for self-peptide/MHC (pMHC) ligands are deleted during thymic development, thereby preventing autoimmunity. In the case of CD4(+) T cells, what is unclear is the extent to which self-peptide/MHC class II (pMHCII)-specific T cells are deleted or b...

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Bibliografische gegevens
Hoofdauteurs: Moon, James J., Dash, Pradyot, Oguin, Thomas H., McClaren, Jennifer L., Chu, H. Hamlet, Thomas, Paul G., Jenkins, Marc K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167500/
https://ncbi.nlm.nih.gov/pubmed/21873213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109806108
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