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Quantitative impact of thymic selection on Foxp3(+) and Foxp3(−) subsets of self-peptide/MHC class II-specific CD4(+) T cells
It is currently thought that T cells with specificity for self-peptide/MHC (pMHC) ligands are deleted during thymic development, thereby preventing autoimmunity. In the case of CD4(+) T cells, what is unclear is the extent to which self-peptide/MHC class II (pMHCII)-specific T cells are deleted or b...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167500/ https://ncbi.nlm.nih.gov/pubmed/21873213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109806108 |
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