Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

Interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) stimulate transcription factors AP-1 and NF-κB through activation of the MAP kinases JNK and p38 and the IκB kinase (IKK), respectively. The TNF-α and IL-1 signals are transduced through TRAF2 and TRAF6, respectively. Overexpressed TRAF2 or TRAF...

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Pubblicato in:	Genes Dev
Autori principali:	Baud, Véronique, Liu, Zheng-Gang, Bennett, Brydon, Suzuki, Nobutaka, Xia, Ying, Karin, Michael
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10346818/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.10.1297
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