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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
Interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) stimulate transcription factors AP-1 and NF-κB through activation of the MAP kinases JNK and p38 and the IκB kinase (IKK), respectively. The TNF-α and IL-1 signals are transduced through TRAF2 and TRAF6, respectively. Overexpressed TRAF2 or TRAF...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316725/ https://ncbi.nlm.nih.gov/pubmed/10346818 |
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