Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM)

Motivation: A critical task in high-throughput sequencing is aligning millions of short reads to a reference genome. Alignment is especially complicated for RNA sequencing (RNA-Seq) because of RNA splicing. A number of RNA-Seq algorithms are available, and claim to align reads with high accuracy and...

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Detalhes bibliográficos
Main Authors: Grant, Gregory R., Farkas, Michael H., Pizarro, Angel D., Lahens, Nicholas F., Schug, Jonathan, Brunk, Brian P., Stoeckert, Christian J., Hogenesch, John B., Pierce, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167048/
https://ncbi.nlm.nih.gov/pubmed/21775302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr427
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