Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe proliferation defect and death in embryonic stem (ES) cells, and peri-implantation embryonic lethality in m...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Liu, Qinghua, Guntuku, Saritha, Cui, Xian-Shu, Matsuoka, Shuhei, Cortez, David, Tamai, Katsuyuki, Luo, Guangbin, Carattini-Rivera, Sandra, DeMayo, Francisco, Bradley, Allan, Donehower, Larry A., Elledge, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2000
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316686/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859164/
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