Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe proliferation defect and death in embryonic stem (ES) cells, and peri-implantation embryonic lethality in m...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Liu, Qinghua, Guntuku, Saritha, Cui, Xian-Shu, Matsuoka, Shuhei, Cortez, David, Tamai, Katsuyuki, Luo, Guangbin, Carattini-Rivera, Sandra, DeMayo, Francisco, Bradley, Allan, Donehower, Larry A., Elledge, Stephen J.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2000
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC316686/
https://ncbi.nlm.nih.gov/pubmed/10859164
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires