The E3 ligase c-Cbl regulates dendritic cell activation

The activation of innate and adaptive immunity is always balanced by inhibitory signalling mechanisms to maintain tissue integrity. We have identified the E3 ligase c-Cbl––known for its roles in regulating lymphocyte signalling––as a modulator of dendritic cell activation. In c-Cbl-deficient dendrit...

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Detalhes bibliográficos
Main Authors: Chiou, Shin-Heng, Shahi, Payam, Wagner, Ryan T, Hu, Hongbo, Lapteva, Natalia, Seethammagari, Mamatha, Sun, Shao-Cong, Levitt, Jonathan M, Spencer, David M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166462/
https://ncbi.nlm.nih.gov/pubmed/21799517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.143
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