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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Parkinson disease (PD) is the second most common neurodegenerative disorder(1,2). Growing evidence suggests a causative role of misfolded forms of the protein, α-synuclein (αSyn), in the pathogenesis of PD(3,4). Intraneuronal aggregates of αSyn occur in Lewy bodies and Lewy neurites(5), the cytopath...

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Bibliografske podrobnosti
Main Authors: Bartels, Tim, Choi, Joanna G., Selkoe, Dennis J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166366/
https://ncbi.nlm.nih.gov/pubmed/21841800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10324
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