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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
Parkinson disease (PD) is the second most common neurodegenerative disorder(1,2). Growing evidence suggests a causative role of misfolded forms of the protein, α-synuclein (αSyn), in the pathogenesis of PD(3,4). Intraneuronal aggregates of αSyn occur in Lewy bodies and Lewy neurites(5), the cytopath...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166366/ https://ncbi.nlm.nih.gov/pubmed/21841800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10324 |
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